The action of isoniazid on the transaminases of Mycobacterium tuberculosis (B.C.G.)
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چکیده
منابع مشابه
The action of isoniazid on the transaminases of Mycobacterium tuberculosis (B.C.G.).
One of the proposed mechanisms for the action of iwonicotinic acid hydrazide (isoniazid) has been the inhibition of enzyme systems which require pyridoxal phosphate (Cymerman-Craig, Rubbo, Willis & Edgar, 1955). However, it appeared unlikely that the inhibition of an enzyme system present in many bacteria could account for the highly specific activity of isoniazid in low concentrations against ...
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15 صفحه اولMechanism of Action of Isoniazid on Mycobacterium bovis Strain BCG.
The mechanism of action of isoniazid (INH) on Mycobacterium bovis strain BCG was studied. The rates of synthesis of deoxyribonucleic acid (DNA), ribonucleic acid (RNA), and protein after the addition of INH to growing cultures were followed by measuring the incorporation of (3)H-thymidine, (3)H-uridine, and (14)C-l-valine, respectively. After the addition of INH, the rate of DNA synthesis began...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1958
ISSN: 0306-3283
DOI: 10.1042/bj0680193